San Francisco 49ers head coach Kyle Shanahan reveals different preparations against the Los Angeles Rams without Aaron Donald ...

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

After their offense went stagnant in Week 2 without one of their star performers, the San Francisco 49ers will look to ...

With injuries sidelining their star athletes, can the 49ers rally together to secure a crucial win against the desperate Rams ...

San Francisco 49ers running back Christian McCaffrey has been placed on the injured reserve, but could miss more time after, ...

San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in ...

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DL Nick Bosa, WR Brandon Aiyuk and LB Fred Warner shared the team's mindset heading into the 2024 season, discussed the ...

Arizona Cardinals running back James Connor joins 'The Insiders' for an exclusive interview on Sept. 18. Former New York ...

Given that the calf strain to 49ers running back Christian McCaffrey suddenly and unexpectedly became an Achilles tendon, too ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...