Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the Buffalo Bills or San Francisco 49ers, or both. Josh Allen's AFC squad entered looking for its sixth straight playoff appearance.

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let's analyze BetM

The Buffalo Bills (9-2) enter a matchup with the San Francisco 49ers (5-6) on Sunday, December 1, 2024 at Highmark Stadium on a

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to miss.

Star pass-catcher George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark Stadium.The Bills sport the seventh-ranked defense this season (19.5 points

Buffalo Bills linebacker Matt Milano is expected to see NFL action on Sunday for the first time since October 2023. The Bills have activated Milano

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio, the Bills Radio Network has stations all across the state. Chris Brown has the play-by-play, Eric Wood is the analyst, and Sal Capaccio is the sideline reporter. The network includes:

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five storylines to watch.