When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan would likely keep him out two weeks.

The Minnesota Vikings and the San Francisco 49ers square off today in a NFL Week 2 showdown. Find out how to watch.

With McCaffrey out, the spotlight turned to the 49ers' defense, but unfortunately, they failed to meet expectations. The Vikings capitalized on key third-down opportunities, converting over 50% of their attempts. This inability to stop drives was a crucial factor in the defeat, highlighting an urgent need for adjustments moving forward.