When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan said would likely keep him out two weeks.

"Nobody knows" when Christian McCaffrey will be ready to return from injured reserve, 49ers coach Kyle Shanahan said Sunday.

49ers coach Kyle Shanahan said the timeline for running back Christian McCaffrey’s return is unknown.