Otisco Lake is the easternmost of New York's eleven Finger Lakes. The 2,048-acre lake is located in Onondaga County, southwest of the city of Syracuse. Otisco Lake's name may have been derived from the Iroquois name for the lake's outlet, Nine Mile Creek, Us-te-ke, meaning "bitter-nut-hickory". At least one older map, published in 1825, has the name sp…Otisco Lake is the easternmost of New York's eleven Finger Lakes. The 2,048-acre lake is located in Onondaga County, southwest of the city of Syracuse. Otisco Lake's name may have been derived from the Iroquois name for the lake's outlet, Nine Mile Creek, Us-te-ke, meaning "bitter-nut-hickory". At least one older map, published in 1825, has the name spelled as "Ostisco". The name may also have been derived from the word ostickney, meaning "waters much dried away", or from the Onondaga word ostick, meaning "the water is low".